What is the principle of drug receptor interaction?
What is the principle of drug receptor interaction?
In present-day pharmacology and medicine, it is usually taken for granted that cells contain a host of highly specific receptors. Drugs act on the cell membrane by physical and/or chemical interactions. This is usually through specific drug receptor sites known to be located on the membrane.
How many types of receptors are there?
Cell-surface receptors come in three main types: ion channel receptors, GPCRs, and enzyme-linked receptors. Ion channel receptors: When a ligand binds an ion channel receptor, a channel through the plasma membrane opens that allows specific ions to pass through.
What are the four primary receptor families?
The four primary receptor families. Although the body has many different receptors, they comprise only four primary families: cell membrane–embedded enzymes, ligand-gated ion channels, G protein–coupled receptor systems, and transcription factors.
What are drug receptors?
7.2 Drug receptors. Receptor is a macromolecule in the membrane or inside the cell that specifically (chemically) bind a ligand (drug). The binding of a drug to receptor depends on types of chemical bounds that can be established between drug and receptor.
What is agonist and antagonist receptors?
An agonist is a drug that binds to the receptor, producing a similar response to the intended chemical and receptor. Whereas an antagonist is a drug that binds to the receptor either on the primary site, or on another site, which all together stops the receptor from producing a response.
What are receptors in pharmacology?
Receptor is a macromolecule in the membrane or inside the cell that specifically (chemically) bind a ligand (drug). The binding of a drug to receptor depends on types of chemical bounds that can be established between drug and receptor.
What are the properties of receptors?
Properties of Receptors:
- Excitability (Fig. 9.4):
- Adequate stimulus is just enough strength of stimulus to excite receptor for production of receptor potential which is sufficient enough to bring about development of an action potential in afferent fiber.
- Specificity:
- Intensity discrimination:
- Adaptation:
What are drugs receptors?
What is the importance of drug receptor?
Receptors are responsible for selectivity of drug action. Accordingly, changes in the chemical structure of a drug can dramatically increase or decrease a new drug’s affinities for different classes of receptors, with resulting alterations in therapeutic and toxic effects.
What is a receptor antagonist drug?
A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.
What determines the lifetime of a drug receptor complex?
The lifetime of the drug-receptor complex is affected by dynamic processes (conformation changes) that control the rate of drug association and dissociation from the target. A longer residence time explains a prolonged pharmacologic effect. Drugs with long residence times include finasteride and darunavir.
Is the drug-receptor complex static?
Accordingly, the drug-receptor complex is not static, but rather there is continuous association and dissociation of the drug with the receptor as long as drug is present. A measure of the relative ease with which the association and dissociation reactions occur is the equilibrium dissociation constant (KD).
What are the properties of drug-receptor interaction?
Two basic properties of the drug-receptor interaction contribute importantly to drug responses: the ability of the drug to bind to its receptor, and the ability of the drug to alter the activity of its receptor.
What is a receptor complex?
Receptor complexes are composed of a core receptor protein or an assembly of receptor subunit proteins that engage with one or more receptor-associated proteins (Fig. 1b ). Receptor-associated proteins directly associate with the receptor protein, often with a marked influence on the structure, function and/or localization of the receptor complex.