What class of drug is dabigatran etexilate mesylate?
What class of drug is dabigatran etexilate mesylate?
Dabigatran is in a class of anticoagulant medications called direct thrombin inhibitors. It works by preventing blood clots from forming in the body.
What is the therapeutic effect of dabigatran?
Dabigatran is used to decrease the risk of stroke and blood clots in patients with a serious heart rhythm problem called nonvalvular atrial fibrillation.
What is dabigatran etexilate mesylate used for?
Dabigatran is used to prevent stroke and harmful blood clots (such as in your legs or lungs) if you have a certain type of irregular heartbeat (atrial fibrillation).
Is dabigatran a narrow therapeutic index?
Its disadvantages are well-known and include a narrow therapeutic index, drug interactions, and the need for frequent monitoring. Dabigatran etexilate, a direct thrombin inhibitor, presents less complexity in prescribing and has emerged as an alternate therapy to warfarin.
Is dabigatran an antiplatelet?
Dabigatran significantly reduced coagulation activity and may have the potential to reduce cardiovascular events when added to dual antiplatelet treatment in the doses 110–150 mg twice daily.
What class of drug is apixaban?
Apixaban is in a class of medications called factor Xa inhibitors. It works by blocking the action of a certain natural substance that helps blood clots to form.
What is Pradaxa classification?
Pradaxa belongs to a class of drugs Anticoagulants, Cardiovascular; Anticoagulants, Hematologic; Thrombin Inhibitors.
What are narrow therapeutic drugs?
Introduction. Narrow therapeutic index drugs are drugs where small differences in dose or blood concentration may lead to serious therapeutic failures and/or adverse drug reactions that are life-threatening or result in persistent or significant disability or incapacity.
What is an example of a narrow therapeutic index drug?
Drugs with a narrow therapeutic index 4 We defined the following drugs to be NTI-drugs: aminoglycosides, ciclosporin, carbamazepine, digoxin, digitoxin, flecainide, lithium, phenytoin, phenobarbital, rifampicin, theophylline and warfarin.
What drug class is rivaroxaban?
Rivaroxaban is in a class of medications called factor Xa inhibitors. It works by blocking the action of a certain natural substance that helps blood clots to form.
What class of medication is warfarin?
Warfarin is also used to treat or prevent venous thrombosis (swelling and blood clot in a vein) and pulmonary embolism (a blood clot in the lung). Warfarin is in a class of medications called anticoagulants (‘blood thinners’). It works by decreasing the clotting ability of the blood.
Is Pradaxa an anticoagulant or antiplatelet?
This is because PRADAXA is a blood-thinning medicine (anticoagulant) that lowers the chance of blood clots forming in your body.
Which anticoagulant medication is classified as a thrombin inhibitor?
Currently, four parenteral direct inhibitors of thrombin activity are FDA-approved in North America: lepirudin, desirudin, bivalirudin and argatroban. Of the new oral DTIs, dabigatran etexilate is the most studied and promising of these agents.
What is therapeutic index of a drug?
The therapeutic index (TI; also known as therapeutic ratio) is a ratio that compares the blood concentration at which a drug causes a therapeutic effect to the amount that causes death (in animal studies) or toxicity (in human studies) [1].
What is therapeutic index or range?
The therapeutic index (TI; also referred to as therapeutic ratio) is a quantitative measurement of the relative safety of a drug. It is a comparison of the amount of a therapeutic agent that causes the therapeutic effect to the amount that causes toxicity.
What is dabigatran etexilate?
Dabigatran etexilate is an oral prodrug of dabigatran, a direct thrombin inhibitor, that provides the first available oral anticoagulant alternative to warfarin for reducing the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation (AF).
Why is dabigatran used to treat atrial fibrillation?
dabigatran is used when the atrial fibrillation is not caused by a heart valve problem. Dabigatran is also used after hip replacement surgery to prevent a type of blood clot called deep vein thrombosis (DVT), which can lead to blood clots in the lungs (pulmonary embolism).
How is dabigatran administered?
Dabigatran etexilate mesylate is administered orally. It is absorbed as the dabigatran etexilate ester, which is then hydrolyzed forming dabigatran, the active moiety. Dabigatran is approximately 35% bound to plasma proteins with a volume of distribution of 50 to 70 L. Pharmacokinetics are proportional to dose.
When can I stop taking dabigatran etexilate?
Do not stop taking dabigatran etexilate without talking to the doctor who ordered it for you. Stopping dabigatran etexilate when you are not supposed to may raise the chance of blood clots. This includes stroke in certain people. You may need to stop dabigatran etexilate before certain types of dental or health care.