Is multiple myeloma a curable cancer?
Is multiple myeloma a curable cancer?
Treatment for multiple myeloma can often help control symptoms and improve quality of life. But myeloma usually can’t be cured, which means additional treatment is needed when the cancer comes back.
What is triple class exposed multiple myeloma?
Patients with relapsed and refractory multiple myeloma (RRMM) have a poor prognosis and limited treatment options after exposure to an immunomodulatory drug, proteasome inhibitor (PI), and anti-CD38 antibody (triple-class exposure [TCE]).
How do you treat triple class refractory multiple myeloma?
The current approaches to the treatment of triple-class refractory disease are limited and include conventional chemotherapy, salvage autologous stem cell transplantation, and recycling previous regimens, each of which have generally had short-lived efficacy.
What is considered relapse in multiple myeloma?
Relapsed or recurrent multiple myeloma is when the cancer comes back after you were in remission.
How often does multiple myeloma relapse?
One 2016 study looked at relapse rates in 511 participants with multiple myeloma following treatment in 2006–2014. Within a 12-month period, 16% of the participants experienced early relapse. However, 84% had a relapse after 1 year or no relapse at the time of the follow-up.
How do plasma cells help fight multiple myeloma?
Plasma cells help you fight infections by making antibodies that recognize and attack germs. Multiple myeloma causes cancer cells to accumulate in the bone marrow, where they crowd out healthy blood cells. Rather than produce helpful antibodies, the cancer cells produce abnormal proteins that can cause complications.
What is the pathophysiology of multiple myeloma?
Multiple myeloma is a monoclonal gammopathy and is the most common primary malignant bone neoplasm in adults. It arises from red marrow due to monoclonal proliferation of plasma cells and manifests in a wide range of radiographic abnormalities.
What are the possible complications of multiple myeloma?
Complications of multiple myeloma include: Frequent infections. Myeloma cells inhibit your body’s ability to fight infections. Bone problems. Multiple myeloma can also affect your bones, leading to bone pain, thinning bones and broken bones. Reduced kidney function.
Which findings on bone scan are characteristic of disseminated multiple myeloma (MM)?
The bone scan appearance of patients with disseminated multiple myeloma is variable due to the potential lack of osteoblastic activity. Larger lesions may be either hyperactive (hot) or photopenic (cold).